Upon launching The Orange Box on Xbox 360, my controller will not respond in the menus or games. How can I fix this?
This error is most likely caused by a wired controller such as a Guitar controller currently plugged into your Xbox 360 console. Please do the following:
Shutdown your Xbox 360.
Remove all controllers and peripherals.
Restart your console using the Xbox button found on your 360 controller to ensure the controller is recognized in the first port.